Dust. Yes, electronics seem to be dust magnets. Other than dusting and blowing with canned air as needed, the biggest thing I found helps is keeping my air filters in my HVAC system clean. Stop the dust before it gets there!
Cables: I have a small home studio. As I got into recording, DAWS and added gear, I discovered I was spending a lot of time getting ready or "hooked up" to record or play or practice. So in 2014-2015 I focused on a set-up that was ready to go. Cables: Out and handing on a hook with easy visual access.